The future of facilities
Facilities as we know them from the past will still exist in future
— however, not with the prevalence as seen before. Current
drug manufacturers and engineering firms alike will have the
ability to make choices from the increasing portfolio of facility
components and designs. As with every aspect in manufacturing processes, there is no “one-size-fits-all” system, neither in an
equipment piece nor unit operation, entire process, or production site. The future processes and facilities will be driven by the
product to be produced within the site by the economic as well
as regional parameters, but the key will be flexibility. Hopefully,
regulators will support such optimization and the potential for
facility redundancy by using the cookie cutter principle and
being able to ramp capacity up and down as needed. Ultimately,
quality will not be compromised, especially with cleanroom
segregation, increasingly compact air handling systems, containment using single-use technology, but most of all creating an
environment minimizing any human failures or effects.
1. H. L. Levine, J. E. Lilja, R. Stock, H. Hummel, S. D. Jones
(2012) Efficient, Flexible Facilities for the 21st Century,
BioProcess International, 10( 11).
2. G. Hodge (2009) The Economic and Strategic Value of
Flexible Manufacturing Capacity. ISPE Strasbourg Conference,
28–29 September 2009, Strasbourg, France.
3. A. Shanley, P. Thomas (2009) Flexible Pharma: Puzzling Out
the Plant of the Future, PharmaManufacturing.com.
4. P. Thomas (2013) On Simplicity, Single-use and Shire,
Pharmaceutical Manufacturing, pp. 12-14.
5. A. Pralong (2013) Single-use technologies and facility layout
– a paradigm shift, Biopharma Asia Magazine, Vol 2, Issue 1.
6. R.B. Holtz, D. Powers (2012) Integration of a Single-
Use Platform Process within an Innovative Facility Design,
Maik W. Jornitz is Chief Operating Officer for G-CON
Manufacturing LLC, manufacturer of G-CON PODS.